A Spada Selected Research

Therapeutics

9/2022	Multicenter retro-prospective observational study on chronic hypoparathyroidism and rhPTH (1-84) treatment.
1/2021	The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells.
1/2018	A novel pathway activated by somatostatin receptor type 2 (SST2): Inhibition of pituitary tumor cell migration and invasion through cytoskeleton protein recruitment.
10/2016	Dopamine receptor type 2 (DRD2) inhibits migration and invasion of human tumorous pituitary cells through ROCK-mediated cofilin inactivation.
4/2015	Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma.
8/2014	Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells.
2/2014	Role of UGT1A1 and ADH gene polymorphisms in pegvisomant-induced liver toxicity in acromegalic patients.
1/2010	Eight-year follow-up of a child with a GH/prolactin-secreting adenoma: efficacy of pegvisomant therapy.
10/2008	Dopamine D2 receptor gene polymorphisms and response to cabergoline therapy in patients with prolactin-secreting pituitary adenomas.
5/2006	Growth hormone replacement therapy in growth hormone deficient children and adults: Effects on hemochrome.

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A Spada Research Topics

Disease

35	Neoplasms (Cancer) 01/2021 - 03/2000
18	Pituitary Neoplasms (Pituitary Adenoma) 01/2019 - 02/2000
17	Adenoma (Adenomas) 10/2017 - 03/2001
10	Acromegaly 12/2011 - 08/2001
6	Cushing Syndrome 04/2018 - 08/2004
6	Insulin Resistance 06/2015 - 05/2004
5	Thyroid Neoplasms (Thyroid Cancer) 01/2021 - 08/2000
5	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2020 - 01/2003
4	Prolactinoma (Prolactinomas) 12/2016 - 10/2008
4	Carcinoid Tumor (Carcinoid) 12/2015 - 07/2003
4	Hyperplasia 07/2007 - 03/2000
4	Infections 10/2005 - 04/2000
3	Hyperprolactinemia 12/2016 - 07/2007
3	Hypertension (High Blood Pressure) 06/2015 - 07/2003
3	Osteoporosis 04/2015 - 07/2003
3	Pseudohypoparathyroidism 09/2012 - 11/2000
3	Growth Hormone-Secreting Pituitary Adenoma 09/2010 - 03/2001
3	Primary Hyperparathyroidism 02/2009 - 03/2000
2	Melanoma (Melanoma, Malignant) 01/2021 - 03/2008
2	Adrenal Insufficiency (Adrenal Gland Hypofunction) 04/2018 - 10/2008
2	Atrophy 07/2015 - 10/2005
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2015 - 05/2004
2	Parathyroid Neoplasms (Parathyroid Neoplasm) 03/2010 - 03/2000
2	Kidney Calculi (Kidney Stone) 09/2009 - 02/2005
2	Hypercalciuria 02/2009 - 02/2005
2	Gastrinoma 03/2007 - 07/2003
2	Carcinogenesis 12/2005 - 09/2001
2	Body Weight (Weight, Body) 10/2005 - 08/2003
2	Pseudopseudohypoparathyroidism 11/2001 - 11/2000
2	Urinary Tract Infections (Urinary Tract Infection) 10/2001 - 09/2001
1	Hypoparathyroidism 09/2022
1	Adrenocortical Carcinoma 01/2021
1	Adrenal Cortex Neoplasms (Adrenocortical Cancer) 01/2021
1	Williams Syndrome (Williams-Beuren Syndrome) 03/2019
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Parathyroid Diseases (Parathyroid Disorders) 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018

Drug/Important Bio-Agent (IBA)

10	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2019 - 03/2001
8	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2001
8	Adrenocorticotropic Hormone (ACTH)FDA Link 04/2018 - 05/2002
7	Octreotide (Sandostatin)FDA LinkGeneric 01/2021 - 08/2001
7	Cyclin D1IBA 12/2015 - 09/2001
7	Insulin-Like Growth Factor I (IGF-1)IBA 02/2012 - 05/2004
6	CalciumIBA 01/2018 - 03/2000
6	somatostatin receptor 2IBA 01/2018 - 08/2005
6	Hydrocortisone (Cortisol)FDA LinkGeneric 10/2017 - 08/2004
6	LipidsIBA 06/2015 - 05/2004
6	Messenger RNA (mRNA)IBA 09/2010 - 03/2001
5	Dopamine Receptors (Dopamine Receptor)IBA 01/2019 - 10/2008
4	Carrier Proteins (Binding Protein)IBA 01/2021 - 05/2001
4	FilaminsIBA 01/2021 - 08/2014
4	Cabergoline FDA LinkGeneric 12/2016 - 10/2008
4	Glucose (Dextrose)FDA LinkGeneric 06/2015 - 07/2009
4	DNA (Deoxyribonucleic Acid)IBA 03/2014 - 08/2001
4	Hormones (Hormone)IBA 09/2012 - 11/2001
4	ProlactinIBA 01/2010 - 07/2007
4	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 11/2009 - 08/2000
4	GhrelinIBA 10/2005 - 07/2003
3	Actin Depolymerizing Factors (Cofilins)IBA 01/2019 - 10/2016
3	Dopamine Agonists (Dopamine Agonist)IBA 12/2016 - 10/2008
3	GTP-Binding Proteins (G-Protein)IBA 09/2010 - 03/2000
3	Somatostatin Receptors (Somatostatin Receptor)IBA 05/2008 - 03/2001
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2007 - 01/2001
3	GonadotropinsIBA 05/2002 - 02/2000
2	Parathyroid Hormone (Parathormone)IBA 09/2022 - 11/2006
2	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 06/2008
2	Biological ProductsIBA 01/2019 - 09/2001
2	Vitamin D FDA LinkGeneric 01/2018 - 01/2017
2	25-hydroxyvitamin DIBA 01/2017 - 07/2003
2	Immunoglobulin M (IgM)IBA 06/2015 - 01/2000
2	Growth Hormone (Somatotropin)IBA 04/2015 - 05/2001
2	2-(4-toluidino)-6-naphthalenesulfonic acid (TNS)IBA 06/2013 - 10/2008
2	Phosphates (Orthophosphate)IBA 09/2009 - 11/2006
2	OxalatesIBA 02/2009 - 02/2005
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2008 - 12/2005
2	RNA (Ribonucleic Acid)IBA 11/2007 - 04/2000
2	Calcium-Sensing ReceptorsIBA 11/2006 - 03/2000
2	Dihydrotachysterol (AT 10)IBA 09/2006 - 10/2005
2	RetinoidsIBA 01/2006 - 12/2005
2	AdiponectinIBA 01/2006 - 05/2004
2	AdipokinesIBA 01/2006 - 05/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2006 - 12/2005
2	Adenosine (Adenocard)FDA LinkGeneric 12/2005 - 05/2001
2	Transcription Factors (Transcription Factor)IBA 12/2005 - 05/2001
2	Gonadotropin-Releasing Hormone (GnRH)FDA Link 08/2004 - 04/2004
2	LeptinIBA 05/2004 - 08/2003
2	Insulin (Novolin)FDA Link 05/2004 - 08/2003
2	Estrogens (Estrogen)FDA Link 05/2002 - 09/2001
2	Succimer (Dimercaptosuccinic Acid)FDA Link 10/2001 - 09/2001
2	ElementsIBA 08/2001 - 05/2001
2	Protein Isoforms (Isoforms)IBA 08/2001 - 08/2000
1	pasireotideIBA 01/2021
1	Insulin-Like PeptidesIBA 01/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2020
1	MineralsIBA 03/2019
1	Dopamine (Intropin)FDA LinkGeneric 01/2019
1	Microfilament Proteins (Actin Binding Proteins)IBA 01/2019

Therapy/Procedure

13	Therapeutics 09/2022 - 07/2003
2	Radiotherapy 01/2011 - 07/2009
1	Adrenalectomy 04/2018